ACE and hypertensive disorder: Despite the availability of antihypertensive drugs, the control of hypertension remains insufficient.18,19,22 According to literature, to control hypertension, the physicians use five classes of antihypertensive drugs classes (diuretics, Calcium channel blocker, Angiotensin converting enzyme inhibitor (ACEi), beta-blockers and Angiotensin II receptor blocker (ARB) apart from modifying certain behaviors in patients.23–26 In this study, physicians used five classes of antihypertensive drugs including central hypertensive drugs which are usually not used in the treatment of hypertension.