LRP8 and autoimmune polyendocrinopathy: Furthermore, anti-ß2-glyocprotein I binding to LRP8 in lipid rafts can decrease phospho-eNOS and NO, suggesting that LRP8 signaling could be a potential mechanism for impaired endothelial function in lupus as well as antiphospholipid syndrome (APS) (Riitano et al., 2023).