Although scarce, studies in B-ALL have demonstrated that EVs derived from leukemic blasts are enriched in tetraspanins (CD9, CD61 and CD81), adhesion molecules (CD29 and CD1446), in addition to lineage-specific markers (CD10, CD19 and CD22) (17, 62). The gene discussed is ITGB1; the disease is acute lymphoblastic leukemia.