Furthermore, proteomic analyze revealed that A Disintegrin and Metalloproteinase 17 (ADAM17) and Autophagy Related Protein 3 (ATG3) molecules were highly expressed in EVs derived from plasma of B-ALL patients, being found enriched in the Notch and autophagy pathways, respectively. This evidence concerns the gene ADAM17 and precursor B-cell acute lymphoblastic leukemia.