TP63 and head and neck squamous cell carcinoma: Using bulk transcriptome data from the TCGA database, GSVA revealed that the abundance of TP63+ SLC7A5+ HNSCC subpopulation significantly increased within HNSCC, contributing to adverse patient outcomes, while exhibiting excellent diagnostic efficacy for identifying HNSCC patients (AUC = 0.887) (Figures 4A-C).