ERT can ameliorate the inflammatory status of FD; In a cohort of 30 FD patients who carried the IVS4 + 919 G>A mutation and developed left ventricular hypertrophy (39), IL-18 levels were decreased after ERT, and IL-18 was significantly increased in the cardiac biopsies of patients with poor ERT responses. Here, IL18 is linked to left ventricular hypertrophy.