TNF and Fabry disease: As shown in Table 2 and Figure 2, IFN-γ (Z=−4.667, P-adj<0.001), IL-1β (Z=−3.214, P-adj=0.002), IL-4 (Z=−3.800, P-adj<0.001), IL-5 (Z=−3.987, P-adj<0.001), IL-6 (Z=−2.887, P-adj=0.005), IL-8 (Z=−5.273, P-adj<0.001), IL-10 (Z=−3.080, P-adj=0.003), IL-17F (Z=−3.727, P-adj<0.000), IL-22 (Z=−4.060, P-adj<0.001), TNF-α (Z=−4.274, P-adj<0.001), and TNF-β (Z=−2.877, P-adj=0.005) expression was significantly higher in 59 FD patients before the initiation of ERT than in the HC group (N=44).