Regarding p53, Δ40p53β, Δ133p53γ, and Δ160p53γ proteoforms showed a high diagnostic ability of CRC patients in comparison to healthy individuals (AUC > 70%), with sensitivities and specificities higher than 67% and 77%, respectively, whereas p53γ, Δ40p53β, Δ40p53γ, Δ133p53γ, and Δ160p53γ proteoforms showed a sensitivity, specificity, and diagnostic ability to discriminate individuals with premalignant lesions from healthy individuals higher than 58%, 51%, and 70%, respectively (Table 5). The gene discussed is TP53; the disease is colorectal carcinoma.