CCNB1 and pachyonychia congenita: On the other hand, another report centered on previous studies in which cyclin B1 autoantibodies were found in PC patients and its inclusion in autoantibody panels could detect the pathology (135, 159, 184) concluded that the combined presence of autoantibodies against cyclin B1 and elevated PSA levels could identify 65.7% of patients with early PC (170).