In this sense, it should be recommendable to include in the same diagnostic/prognostic panel, promiscuous cancer specific autoantibodies as p53, MUC1, NY-ESO-1, MAGEA1, and Survivin, among others, together with specific autoantibodies of different cancer types as HER2 or BRCA2 in BC, SOX2, or GBU4-5 in LC, AMACR, or PARK7 in PC, and CEA, PIM1, or GTF2B in CRC to be able to detect not only cancer but its exact localization. This evidence concerns the gene SOX2 and colorectal carcinoma.