CTAG1B and laryngotracheoesophageal cleft: Regarding the diagnostic signatures based on the detection of proteins and autoantibodies, the PAULA (Protein Assay Using Lung Cancer Analytes) test from 20/20 Genesystems uses a panel of 4 TAA (CEA, CA-125, and CYFRA 21–1) and one autoantibody (NY-ESO-1) to discriminate between LC patients and controls with high sensitivity and specificity (109).