PDHA1 and Sepsis: Studies in a mouse model of burn-induced sepsis have revealed that glutamine augments the activity of pyruvate dehydrogenase (PDH) in macrophages; mechanistically, glutamine attenuates SIRT5-dependent desuccinylation of PDHA1, thus reinstating PDH activity, bolstering M2 polarization in macrophages, and ameliorating burn-induced sepsis in mice.