Seventeen studies, including 18 group comparisons, reported ICAM-1 concentrations in 962 SSc patients (mean age 53 years, 85% females) and 645 healthy controls (mean age 45 years, 65% females) (64–67, 69, 71, 76, 77, 83, 84, 92, 94, 95, 97, 101, 103, 104) (Table 1). The gene discussed is ICAM1; the disease is systemic sclerosis.