Eighteen studies, including 19 group comparators, assessed E-selectin concentrations in 1,293 SSc patients (mean age 54 years, 86% females) and 677 healthy controls (mean age 48 years, 70% females) (63, 66, 67, 70, 73, 74, 76, 79, 80, 84–86, 91–93, 96, 103, 104) (Table 1). The gene discussed is SELE; the disease is systemic sclerosis.