For instance, BNT162b2 expresses RBD, the CONVIDECIA vaccine expresses the S protein, inactivated vaccines use whole virus inactivation, the INO-4800 vaccine expresses the S protein, and the Recombinant COVID-19 Vaccine (Sf9 cells) contains S-RBD complexes, thus the immunological effects are also influenced by the different vaccine expression and delivery systems. This evidence concerns the gene PROS1 and COVID-19.