LOX-1 is a scavenger receptor for oxidized low density lipoprotein receptor 1 (ox-LDL) which plays an important role in the development of atherosclerosis (Xu et al., 2013), we analyzed the plasma levels of ox-LDL and found it to be significantly higher in plasma of CCM patients vs. controls. This evidence concerns the gene OLR1 and cerebral cavernous malformation.