Here we report an initial experience with the use of LOX-1 [lectin-like oxidized low-density lipoprotein (LDL) receptor-1], a transmembrane receptor found on endothelial cells which is activated in response to oxidative stress, abnormal hemodynamic flow, and inflammation—all conditions present in CCM (Chen et al., 2002; Zeya et al., 2016; Mentrup et al., 2020). The gene discussed is OLR1; the disease is cerebral cavernous malformation.