Another study in 292 lung adenocarcinoma patients show opposite results that MDM2 rs2279744 was associated with an increased risk of grade 3-4 hematologic toxicity in recessive model (OR = 2.128; 95% CI: 1.198–3.777; p = 0.010) (Guo et al., 2016). This evidence concerns the gene MDM2 and lung adenocarcinoma.