In keeping with this, XRCC1 rs25487 was identified as risk factors for grade 3-4 leukocytopenia in recessive model (OR = 2.841; 95% CI: 1.051–7.681; p = 0.040), grade 3-4 thrombocytopenia in additive model (OR = 2.033; 95% CI: 1.113–3.715; p = 0.021) in discovery cohort of 437 NSCLC patients (Zheng et al., 2017). This evidence concerns the gene XRCC1 and non-small cell lung carcinoma.