In a study of 285 NSCLC patients, XRCC1 rs25487 polymorphism showed significant associations with increased risk of grade 3-4 anemia, grade 3-4 neutropenia, grade 3-4 leukopenia and grade 3-4 thrombocytopenia (Bushra et al., 2020). This evidence concerns the gene XRCC1 and Decreased total leukocyte count.