HBEGF and glomerulonephritis: For example, several studies have shown that HB-EGF, a ligand for EGFR, appears to be a key player in mediating pathological changes in the glomerulus resulting in glomerulonephritis (Feng et al., 2000; Tang et al., 2013a; Tang et al., 2013b; Hénique et al., 2013).