Chronic or prolonged intermittent hyperglycemia associated with diabetes mellitus can lead to a general dysfunction in the kidney (e.g., in mesangial cells, podocytes, endothelial and tubular epithelial cells) through multiple pathological mechanisms including excess production of reactive oxidative species (ROS) or reactive nitrogen species (RNS), and downstream activation of several signaling networks including EGFR (for a recent review, see also Sheng et al., 2021). The gene discussed is EGFR; the disease is Hyperglycemia.