While studying the possible underlying mechanisms for this, it was found that CKD-bearing mice given Tempol (a Superoxide Dismutase-Mimetic) exhibited reduced renal fibrosis along with decreased signaling via TGF-ß/Smad3, EGFR and MAPK pathways (Ding et al., 2015). This evidence concerns the gene EGFR and renal fibrosis.