Inhibiting AREG, a ligand of EGFR, by AREG-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG) in animal models of renal fibrosis resulted in decreased expression of fibrotic markers, including α-smooth muscle actin, fibronectin, α1(I) collagen, and α1(III) collagen. This evidence concerns the gene EGFR and renal fibrosis.