CCN2 and renal fibrosis: Similarly, supportive of the crucial role that EGFR plays in renal fibrosis induced by Ang II, Ang II-treated SV40 mesangial cells in vitro were administered novel small molecules or short hairpin RNA as inhibitors of EGFR, that resulted in preventing the accumulation of connective tissue growth factor (CTGF) and collagen IV, known fibrotic markers (Qian et al., 2016).