EGFR and cancer: Indeed, small molecule EGFR inhibitors such as Gefitinib and Erlinotib have been clinically used in cancer chemotherapy since their FDA approval in the early 2000s (Karachaliou et al., 2019; Abourehab et al., 2021; Singh et al., 2023; Zubair and Bandyopadhyay, 2023).