EGFR and focal segmental glomerulosclerosis: Supportive of the role of EGFR signaling in glomerulonephritis is the finding that extracellular signal-regulated kinases 1/2 (ERK1/2), which are downstream signalling effectors for EGFR, are also activated in focal segmental glomerulosclerosis that was induced by a gain of mutation in the transient receptor potential C6 (TRPC6) (Chiluiza et al., 2013).