A more recent study by Li et al. 2021 showed that selective podocyte EGFR deletion led to relative podocyte preservation and marked reduction in albuminuria and glomerulosclerosis, renal proinflammatory cytokine/chemokine expression, and decreased profibrotic and fibrotic components in nos3 −/−; db/db mice. Here, NOS3 is linked to glomerulosclerosis.