It is investigated that the anti-inflammatory properties of mianserin, a serotonin (5HT) receptor antagonist, was able to inhibit the endosomal TLR8 in primary human cells and inhibited the spontaneous release of TNF and IL-6 from rheumatoid arthritis synovial membrane cultures (Sacre et al., 2008). Here, TNF is linked to rheumatoid arthritis.