Reduced HGF/MET signaling contributes to synaptic pathology in the 5 × FAD mouse model of AD (Wei et al., 2022); while FGF2 gene transfer restores hippocampal functions in APP/PS1 mice (Kiyota et al., 2011); CRH (corticotropin-releasing hormone) has been proposed to play important roles in AD and other dementias (Rehman, 2002). This evidence concerns the gene PSEN1 and Alzheimer disease.