SAS may harm other tissues and organs via HIF-1, SAS can accelerate the progression of aortic dissection through the ROS-HIF-1α-MMPs related pathway (108), as well as exacerbate neuroinflammation and apoptosis in early brain injury after subarachnoid hemorrhage via the ASC/HIF-1α pathway (109). The gene discussed is HIF1A; the disease is SATB2 associated disorder.