Disturbances in metabolic processes (such as increased blood sugar levels and elevated levels of triglycerides), as well as systemic dysfunctions (such as oxidative stress, inflammation, and impaired response to insulin), are some of the contributing factors in individuals with diabetes, particularly those with type 2 diabetes mellitus (T2DM), that result in heightened platelet reactivity. The gene discussed is INS; the disease is type 2 diabetes mellitus.