In addition, several classes of oral hypoglycemic medications are utilized, including sulfonylureas, meglitinides, biguanides (such as metformin), thiazolidinediones, α-glucosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, and SGLT2 inhibitors [7-9] with metformin generally recommended as the initial treatment for T2DM in most guidelines [10]. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.