CDK2 and cancer: Therefore, drugs such as flavopiridol, roscovitine, olomoucine, adapalene, and kenpaullone, which are reported to be CDK2 inhibitors, and sorafinib, aspirin (salicylic acid), etc., which have been reported to cause downregulation of the enzyme via various mechanisms have been employed as therapies for these cancers (Oh et al., 2012; Cicenas et al., 2015; Dachineni et al., 2015).