In this respect, PRKDC mutations (67% in this series and in the report from Shlien13) were highly associated with MSI-high status,35 high tumor mutation burden, and inflamed tumor microenvironment.36,37 In our small series, there was no correlation between the presence of PRKDC mutations and T-cell immune infiltrates nor PD1 expression (data not shown). The gene discussed is PRKDC; the disease is neoplasm.