Links between CMMRD and NF1 have already been mentioned and they may be more complex than previously thought.27-30NF1 somatic mutations are rarely found in pediatric HGGs outside CMMRD predisposition and SETD2 mutations have been described in around 15% of supratentorial pediatric glioblastomas.26. This evidence concerns the gene SETD2 and glioblastoma.