Among the mutated genes identified with potential co-driver role, several genes that could play a role in HGG development were identified: TP53, NF1, ATRX, PRKDC, PHF3, SETD2, ZEB2, POU3F2. In addition, 3 genes involved in ciliary dyskinesia were identified: HYDIN, DNAH11, and FAM179B as well as 2 olfactory receptor genes: OR4M2 and OR4C3. The gene discussed is PHF3; the disease is primary ciliary dyskinesia.