Some of the frequently mutated genes have been rarely reported in brain tumors according to the COSMIC database: EPH2B (67% vs 1.11%), DICER1 (67 vs 1.25%), KMT2B (67% vs 1.46%), ATRX (67% vs 13.95%) as well as several muscular genes (DMD, MYO10, MYO9B, MYH6) (P < .00001, Fischer exact test). This evidence concerns the gene ATRX and brain neoplasm.