MIF and central nervous system neoplasm: Although not studied in primary CNS tumors, p425 decreased colorectal carcinoma cell migration in vitro, and MIF administration increased cancer metastasis in vivo.143 L2-4048 is a chimeric molecule composed of ibudilast and the tautomerase site-binding segment of p425.144 Initial mechanistic evaluation supports improved activity against MIF due to both its inhibition of the MIF tautomerase site and its promotion of MIF-MIF binding, which sequesters MIF from binding to its targets.