(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) was first synthesized as a reversible, competitive inhibitor of the MIF tautomerase site.111 ISO-1 demonstrated dose-dependent effects on arachidonic acid secretion, dexamethasone regulation, and glioblastoma cell proliferation.112,113 Specifically, ISO-1 reduced in vitro glioblastoma cell growth and increased CD74 protein expression. This evidence concerns the gene CD74 and glioblastoma.