MIF and neoplasm: Certain genetic polymorphisms have been linked to greater CD8+ T lymphocyte infiltration in the glioblastoma TME, but significant associations with overall survival have not been demonstrated.85 In meningioma, tumor cell of chromosome monosomy 22 has been associated with decreased MIF gene expression and increased leukocytic tumor infiltration.96 Chromosome 22 is monosomic in meningioma and contains the neurofibromin 2 (NF2) gene, as well as the MIF gene.