Subsequent theories, including the tau hypothesis (Wood and Zinsmeister, 1989), the mitochondrial cascade hypothesis, and the immune dysfunction hypothesis, have broadened our comprehension of the multifactorial nature of AD (Arshavsky, 2020; Ashleigh et al., 2023; Chatanaka et al., 2023; Swerdlow, 2023). This evidence concerns the gene MAPT and Alzheimer disease.