MAPT and Alzheimer disease: Research consistently associates AD pathogenesis with the abnormal buildup of Aβ and tau protein hyperphosphorylation, both contributing to neuronal degeneration and loss of synaptic plasticity, progressively impairing cognitive functions (Boxer and Sperling, 2023; Chen and Yu, 2023; Kim et al., 2023; Yadollahikhales and Rojas, 2023; Jia et al., 2024; Litvinchuk et al., 2024).