Additionally, the activation of aerobic glycolysis also requires the dysregulation of glycogenolysis, whose enzymes-PEPCK, FBPase, and G6Pase-antagonize glycolysis function, particularly in the cancer context (Wang and Dong, 2019).Our study found that G6PC is notably downregulated, suggesting its key role as a suppressor of aerobic glycolysis in IBD and SI-NET. Here, G6PC1 is linked to inflammatory bowel disease.