Diclomax and everolimus can be used as inhibitors of mammalian target of rapamycin (mTOR) to prolong progression‐free survival of patients with ccRCC by regulating hypoxia‐inducible factors associated metabolism and cellular proliferation through the PI3K‐Akt pathway [38, 39]. The gene discussed is MTOR; the disease is nonpapillary renal cell carcinoma.