On October 1, 2023, PubMed was used to search the literature for the above seven genes with prognostic significance for ccRCC patients in relation to ccRCC using the search terms “clear cell renal carcinoma,” “renal clear cell carcinoma,” “ccRCC,” and “KIRC,” which showed that MTCP1, EFNA3, and IL2RG had not yet been investigated and were considered to be novel genes related to diagnosis and prognosis of ccRCC patients. This evidence concerns the gene IL2RG and clear cell renal carcinoma.