Some important transcriptional genes were involved in the occurrence and development of ccRCC, for example, in the Von Hippel‐Lindau (VHL) gene‐mediated PI3K‐Akt pathway, deletion or mutation of VHL results in up‐regulation of the PI3K pathway to make ccRCC more aggressive [47]. This evidence concerns the gene PIK3CG and nonpapillary renal cell carcinoma.