Nine of these genes with AUC < 0.85, namely THBS2 (AUC = 0.6839), IL7R (AUC = 0.723), COL6A3 (AUC = 0.7419), BDNF (AUC = 0.7627), PIK3CG (AUC = 0.7758), EGFR (AUC = 0.7975), COL1A2 (AUC = 0.8059), CCND2 (AUC = 0.8373), and OSMR (AUC = 0.8495), indicated that these nine genes had poor diagnostic accuracy and might be likely to lead to misdiagnosis of ccRCC. This evidence concerns the gene COL6A3 and nonpapillary renal cell carcinoma.