In this study, we identified three PI3K‐Akt pathway‐related genes (MTCP1, EFNA3, and IL2RG) that were significantly associated with clinical outcomes in ccRCC using the TCGA and GEO datasets, and constructed prognostic gene models based on the three genes that could be used independently of other conventional clinical factors in patients with ccRCC as an independent prognostic factor for evaluating the survival of patients with ccRCC. This evidence concerns the gene EFNA3 and nonpapillary renal cell carcinoma.