Results showed that partial phosphorylation of tau protein occurs in the PRR and C-terminal at Braak stages 0–2; more phosphorylation sites are detected in these two regions at Braak stages 3–4; acetylation and ubiquitination occur in the MBD in addition to the increased phosphorylation sites in Braak stages 5–6; and various post-translational modifications significantly increase in the most severe AD patients [383]. This evidence concerns the gene MAPT and Alzheimer disease.