Our observation here show that HDAC6 inhibition lowered the CD206 (M2 macrophage marker) protein expression in the infracted myocardium, indicating that the impaired M2 polarization might be due to the reduction of HDAC6/ TGF‐β1‐TGF‐βR1 in post‐MI heart. Here, HDAC6 is linked to myocardial infarction.