Collectively, these observations suggest that HADC6 may act as a key mediator of TGF‐β1/TGF‐βR1‐mediated Samd2/3‐Nkx‐2.5 and ‐Ekr1/2 signalling activation in CFs during cardiac remodelling and fibrosis in post‐MI. Here, NKX2-5 is linked to myocardial infarction.