VCAN and neoplasm: Different TAM subtypes had different expression patterns (Fig. 2c & Fig S2): TUBA1B+ TAMs (n = 274) marked by TUBA1B, C1QC + TAMs (n = 338) marked by C1QC and C1QB, IL1B+ TAMs (n = 286) marked by IL1B and CCL3, CXCL11+ TAMs (n = 32) marked by CXCL11 and CXCL10, VCAN+ TAMs (n = 271) marked by VCAN and S100A8, SLC40A1+ TAMs (n = 579) marked by SLC40A1 and FOLR2, APOC1+ TAMs (n = 779) marked by APOC1 and ACP5. Similarly, the proportion of 7 TAM subtypes varied as the progression and molecular subtypes of the tumor differ (Fig. 2f).