A distinctive feature of VCAN+ TAMs was the high expression level of angiogenic features including VCAN and THBS1 (Fig. 2b, c & Fig. S2), which are often upregulated in the hypoxic regions of the cancer TME [38] Apart from the upregulation of VEGFA-VEGFR2 (Fig. 2e) signaling pathway directly influencing angiogenesis, transactivation response element RNA-binding protein (TRBP) pathways are also capable of promote vascularization by TRBP binding to specific mRNA [39]. Here, VCAN is linked to cancer.