AKT1 and neoplasm: S100 family members S100A8/A9 facilitating the migration of monocytes and neutrophils [40] are capable of inducing pro-inflammatory cytokines in monocytes and macrophages via the NF-κB and p38 MAPK pathways [41], thus promoting migration and invasion of tumor cells through Akt and p38 MAPK signaling [42].