The single nucleotide polymorphisms (SNPs) of protein tyrosine phosphatase non-receptor types 2 and 22 (PTPN2/22), specifically PTPN2:rs478582 and PTPN22:rs2476601, may be associated with hyperimmune response and exacerbation of inflammation in RA patients. The gene discussed is PTPN2; the disease is rheumatoid arthritis.