FOXP3 and neoplasm: Indeed, the survival analyses by TIMER2.0 [26–28], which computationally predicts the abundance of TIC subsets in tumors from the TCGA data, suggested that high CD8+ T-cell infiltration has tumor-suppressing effect, and that high CD25 and FOXP3 expressions both have antagonizing effects against that, resulting in the opposite prognostic significances (Fig. 4B).