Indeed, the survival analyses by TIMER2.0 [26–28], which computationally predicts the abundance of TIC subsets in tumors from the TCGA data, suggested that high CD8+ T-cell infiltration has tumor-suppressing effect, and that high CD25 and FOXP3 expressions both have antagonizing effects against that, resulting in the opposite prognostic significances (Fig. 4B). This evidence concerns the gene CD8A and neoplasm.