While tumor-SN are devoid of CCL22 secretion, the addition of PBMCs to these SN led to a significant induction of CCL22-production (Fig. 5C), thus suggesting PBMCs are the main source of CCL22.To exclude that, inversely, CCL22 is induced in tumor cells through the SN of PBMCs, we incubated EC cell lines in PBMC culture SN. The gene discussed is CCL22; the disease is neoplasm.