Exenatide (Ex), a 39-amino-acid GLP-1 analogue peptide, is a potent agonist with high affinity for GLP-1Rs and has a significantly longer biological half-life than the exogenously administered GLP-1, which makes it an efficient treatment option in noninsulin-dependent diabetes mellitus [14–17]. The gene discussed is GCG; the disease is type 2 diabetes mellitus.