FGF1 and pachyonychia congenita: The extensive remodeling of the gene expression signature of PC cells include the suppression of a broad range of angiogenic and angiocrine factors, such as IGF139, CCN240, CXCL5, CXCL841, EDN142, ITGAV43, TNF44, MMP1445, FGF1, and FGF246, associated with the downregulation of oncogenes, such as PTGS247, and a key driver of inflammation and PC cell survival, namely, NFKB124, and the upregulation of tumor suppressors, such as CDH148, DKK349,50, and PTEN51.