AR and neoplasm: Both AR+DU145 and AR-PC3 cells, as well as tumors originating from their subcutaneous (s.c.)implantation in NSG mice (Fig. 1a, b and c), express PSCA (Fig. 1b, Supplementary Fig. 4a, b); therefore, to increase NxP accumulation at the tumor site, anti-human (h) PSCA Abs were conjugated to the PEG derivatives present on the external bilayer of preformed NxPs using an aldehyde-maleimide reaction.