In the DU145 tumor model, the efficacy of the nanotherapy in slowing tumor growth and improving survival was lower than what was observed when the IL30 gene was deleted in cancer cells before xenograft implantation, however, the antimetastatic effect was comparable to that of DU145 IL30KO tumors of the same size and resulted in more than half of the animals being free from lung metastases. The gene discussed is IL27; the disease is cancer.