The extensive remodeling of the gene expression signature of PC cells include the suppression of a broad range of angiogenic and angiocrine factors, such as IGF139, CCN240, CXCL5, CXCL841, EDN142, ITGAV43, TNF44, MMP1445, FGF1, and FGF246, associated with the downregulation of oncogenes, such as PTGS247, and a key driver of inflammation and PC cell survival, namely, NFKB124, and the upregulation of tumor suppressors, such as CDH148, DKK349,50, and PTEN51. This evidence concerns the gene CXCL5 and pachyonychia congenita.