IL27 and pachyonychia congenita: In this study, using a microfluidic device, we designed and synthesized a nonimmunogenic biocompatible cationic lipid nanocomplex coated with PEG (NxP) and conjugated with anti-PSCA antibodies (Abs) for the selective delivery of the Cas9 guide (g) RNA-IL30 complex to human (h)-derived PSCA+IL30+ PC xenografts and in a syngeneic, fully immunocompetent, PSCA+IL30+ PC model.