IL27 and neoplasm: Immunopathological analysis of DU145 and PC3 tumors revealed a lack of IL30 expression following Cas9hIL30-hPSCA NxP treatment, as observed in IL30KO tumors, and extensive areas of ischemic hemorrhagic necrosis in association with poor vascularization and reduced tumor cell proliferation (Fig. 5a, b and Supplementary Table 6), compared with tumors from PBS- or empty-hPSCA NxP-treated mice.