IL27 and pachyonychia congenita: In addition, in the syngeneic PC model, treatment with Cas9gRNA-mIL30-loaded nanoparticles prevents intratumoral infiltration of macrophages, MDCs and granulocytes and inhibits Treg52 and ILC353–55 influx, thus abrogating the immune cell landscape orchestrated by IL30 overproducing tumor12.