To compare the effects on tumor growth and progression of the immunoliposome-based delivery of CRISPR/Cas9gRNA-hIL30 complex versus a direct IL30 gene editing in PC cells, which generated IL30KO-DU145 and IL30KO-PC3 cells, in addition to three groups of NSG (NOD scid gamma) mice s.c. implanted with wild-type DU145 or PC3 cells, and then treated with Cas9hIL30-hPSCA NxPs, or empty-hPSCA NxPs, or PBS; two groups of mice implanted with IL30KO-DU145 or IL30KO-PC3 cells, and then treated with PBS, were included in the study. The gene discussed is IL27; the disease is neoplasm.