CXCL13 and neoplasm: Cell-cell interaction analysis showed that B cells might interact with CD8_C8_CXCL13 cells and regulate their activation and cytotoxicity in TLS of NPC, consistent with findings in other cancers45,46, suggesting that CD8_C8_CXCL13 T cells might be tumour reactive T cells in response to tumour antigens presented by B cells in TLS.