CD8A and cancer: We also identified various cell clusters according to their expression profiles using graph-based clustering implemented in the Seurat package, including 97,360 B cells, 88,009 CD4+ T cells, 95,686 CD8+ T cells, 20,051 NK cells, 21,088 myeloid cells, 1,652 cancer-associated fibroblasts (CAFs), 1,550 endothelial cells, and 15,666 malignant cells (Fig. 1b and Supplementary Fig. 1d-h).