To effectively reverse osteoporosis, a specially designed nanocatalytic medicine was fabricated by loading bone targeting group calcein to a calcium-aluminium LDH (CALC).102 As shown in Fig. 4a, CALC neutralised acidic microenvironment to suppress osteoclast activities at the lesion site and release Ca2+ for the synthesis of CaP nanoparticles in situ with endogenous phosphate cations. This evidence concerns the gene MICU1 and osteoporosis.