TGFBR1 and colorectal carcinoma: Combining the results from HT29 and DLD1 cells, we showed that galectin-8 regulates TGF-β-mediated noncanonical signaling by disrupting TGF-β binding to TβRII in CRC cells without or with heterozygous TGFBR1/2 mutations, and represses cell migration.