MAPK8 and colorectal carcinoma: The activation of JNK appeared to be critical for the pro-apoptotic effect of rGal-8 on CRC cells, as the JNK inhibitor SP600125, but not the ERK inhibitor PD98059, attenuated the apoptosis and the loss of viability caused by rGal-8 (Fig. 5G, H; Supplementary Fig. S5D).