Additionally, rGal-8 maintained stable surface expression of TβRII, counteracting the typical transient increase and subsequent decrease observed after TGF-β stimulation (Supplementary Fig. S9C, D), indicating a multifaceted impact on TGF-β-mediated responses by galectin-8 in CRC cells. This evidence concerns the gene TGFBR2 and colorectal carcinoma.