We next sought to further understand the impact of galectin-8 in response to TGF-β in CRC cells with a heterozygous mutation by using DLD1 cells harboring a mutant TGFBR1 allele (TGFBR1*6A), which was shown to act as a tumor susceptibility allele that stimulates cell growth and cancer development when exposed to TGF-β [24]. Here, TGFB1 is linked to cancer.