HLA-DRB5 and Mental deterioration: Three genes identified in a previous study [16] were replicated from the meta-analysis XWAS of all three cohorts; these genes were GRIA3, GRIPAP1 and UBL4A. As well as being associated with slower cognitive decline in women but not men, GRIA3 is known to be involved in memory and learning and is highly correlated to HLA-DRB5, which is associated with AD [69].