Two additional gene-wide significant genes were identified in the BDR data in the gene-based analysis; these genes are BGN and HAUS7. BGN has been associated with amyloid metabolism in AD [70], inflammatory state in obesity and type 2 diabetes [71] and is known to be a central gene in a network in the brain in response to fructose consumption [72]. The gene discussed is BGN; the disease is obesity due to melanocortin 4 receptor deficiency.