Similarly, the ligand‐receptor pairs SPP1‐ITGA5_ITGB1, SPP1‐ITGA8_ITGB1, SPP1‐ITGA9_ITGB1, as well as SPP1‐ITGAV_ITGB1, were also identified in the communications of both cancer cells and T cells with VasECs specifically in BM, as well as in the communications of senescent cancer cells with VasECs (Figure 6E,F, Figure S13C). This evidence concerns the gene SPP1 and cancer.