Additionally, SPP1 as a ligand could induce communications of pan T‐cell subtypes to cancer cells specifically in BM or to senescent cancer cells via adhesive receptors ITGAV_ITGB1, ITGAV_ITGB5 and ITGAV_ITGB6 (Figure 6D, Figure S13B). This evidence concerns the gene ITGB6 and cancer.