One drug-related treatment-emergent SAE (vadadustat once-daily group: elevated alanine aminotransferase [ALT] and aspartate aminotransferase [AST] >3 times the upper limit of normal [ULN]; vadadustat three-times-weekly group: hypoglycemia) was reported in each vadadustat group (Table 3 and Supplemental Table 10). The gene discussed is GPT; the disease is Hypoglycemia.