Measurement of NP has a significant diagnostic contributing effect in primary care patients suspected of HF.15–17 In a cross-sectional diagnostic study reporting on how often GPs performed additional investigations in patients suspected of new-onset HF, almost 30% had HF, and NT-proBNP showed to be the most powerful diagnostic test.15 NPs are also used to guide treatment decisions. This evidence concerns the gene NPPB and hydrops fetalis.