This is consistent with the results of our reanalysis of the single-cell RNA-seq (scRNA-seq) data of published mouse atherosclerosis studies16,22–24, which shows that prototypical genes associated with arterial resident-like macrophages, including Lyve1 and Nrp1, are progressively downregulated with increasing durations on a high-fat diet (Extended Data Fig. 7a,b). The gene discussed is LYVE1; the disease is atherosclerosis.