To examine the specific role of resident arterial macrophages in atherosclerosis, we focussed on Lyve1-expressing macrophages, which reside in the adventitia of healthy arteries21 and are part of intimal resident-like TLF macrophages in atherosclerotic lesions22, although intimal TLF macrophages often do not express LYVE1 protein. Here, LYVE1 is linked to atherosclerosis.