LDLR and atherosclerosis: Reconstitution of Ldlr−/− mice with Lyz2cre+/−Nrp1flox/flox bone marrow increased the development of atherosclerosis under the cWD compared with reconstitution with Lyz2cre+/−Nrp1+/+ bone marrow (Fig. 4g), independently of changes in circulating cholesterol levels (Extended Data Fig. 10c).