We found that reconstitution of Ldlr−/− mice with Lyz2cre+/−Spicflox/flox bone marrow substantially accelerated atherosclerosis in response to cWD compared with reconstitution with Lyz2cre+/−Spicflox/+ control bone marrow (Extended Data Fig. 6c,d), despite similar circulating cholesterol levels (Extended Data Fig. 6e). The gene discussed is LDLR; the disease is atherosclerosis.