Several studies have associated the genetic variant of CD226 (rs763361T; 307Ser) with increased risk of developing inflammatory diseases including MS.12 This disease-associated single-nucleotide polymorphism (SNP) is located in the coding region and generates a glycine-to-serine variation at residue 307 in the cytoplasmic region of CD226. This evidence concerns the gene CD226 and myeloid sarcoma.