TNF and cancer: There is abundant evidence that suggests that lysosomal membrane damage, such as damage by LMP, can trigger the release of hydrolytic enzymes, particularly cathepsin B, which in turn trigger necroptosis.[12] The activation of phosphorelated (P)‐MLKL in HT29 and MCF7 cancer cells leads to TNF‐α–induced, receptor‐interacting protein kinase 1 (RIPK1)/RIPK3/MLKL‐dependent necroptotic cell death.