To assess whether sense strand–derived KGREG peptide products accumulate in brains of patients with CANVAS, we performed immunohistochemistry on CANVAS (n = 4) as well as control [n = 16, including disease controls from cases of spinocerebellar ataxia type 3 (n = 1), C9orf72-associated FTD/ALS (n = 2), Huntington’s disease (n = 2), and 11 nondisease controls] postmortem brain samples obtained from the University of Michigan Brain Bank, MassGeneral Brigham SCiN, Queen Square Brain Bank UCL, and the Netherlands Brain Bank (Fig. 2F, fig. The gene discussed is C9orf72; the disease is frontotemporal dementia.