MAP3K14 and Alzheimer disease: Ectodermal dysplasia with nail dystrophy, sparse hair, and alopecia, as described in a third of patients with AD p52LOF/IκBδGOF and in all four patients with AR partial IKK-α deficiency, was not reported in the seven NIK-deficient patients, and subtle manifestations were found in only one of the nine patients with AR RelB deficiency (P2, sparse body hair during childhood) (8, 15, 18, 19).