We recruited a second patient (P2) born to nonconsanguineous parents, of Irish, Scottish, French, and German descent, a 33-y-old man with a history of chronic mucocutaneous candidiasis (CMC), recurrent bacterial otitis, pneumonia, and peritonitis, osteomyelitis, large B cell lymphoma, chronic malabsorption syndrome with cholestatic liver disease, portal hypertension, and thyroid disease (no detectable auto-Abs against TPO or TG detected). The gene discussed is TPO; the disease is liver disorder.