Therefore, this research evaluated if the radiation treatment of the bladder cancer cells could affect the immunity function of DCs by detecting the expression levels of costimulatory molecules CD80 and CD86, chemokine receptors CCR5 and CCR7, antigen presentation related molecule HLA-DR and DC signature marker CD11c in imDC incubated for 48 hr with the medium derived from the irradiated cells. The gene discussed is CCR5; the disease is urinary bladder cancer.