To better investigate changes of mitochondrial homeostasis in PBMCs of SLE patients and healthy controls, we subsequently analysed the expression levels of genes involved in mitochondrial biogenesis (TFAM, SIRT1), fusion and fission pathway (MFN1 and MFF, respectively) and mitophagy (PRKN2). The gene discussed is MFF; the disease is systemic lupus erythematosus.