To better investigate changes of mitochondrial homeostasis in PBMCs of SLE patients and healthy controls, we subsequently analysed the expression levels of genes involved in mitochondrial biogenesis (TFAM, SIRT1), fusion and fission pathway (MFN1 and MFF, respectively) and mitophagy (PRKN2). Here, MFN1 is linked to systemic lupus erythematosus.