Our results showed a significant decrease in mRNA expression levels of SIRT1, MFN1 and PRKN2 in SLE patients when compared to the controls (P = 0.00001 for SIRT1, P = 0.0150 for MFN1 and P = 0.0009 for PRKN2). The gene discussed is SIRT1; the disease is systemic lupus erythematosus.