25 days later he was readmittedwith severe systemic illness consisting of widespread rash, facialangioedema and lymphadenopathy (eosinophilia of 4.18 × 109/L,neutrophils 12.4 × 109/L, CRP 27.5 mg/L, IgE > 4000 IU/mL).Onadmission liver function tests and lymphocyte phenotyping were normal,antistreptolysin O titer was negative, as were EBV, VCA, toxoplasma,and HIV serology. This evidence concerns the gene IGHE and Increased total eosinophil count.