BDNF and obesity due to melanocortin 4 receptor deficiency: Overall, our results align with the presented partial model and support the notion that unless intervened, HFD/obesity‐associated neuroinflammation may persist because of compromised antioxidant defense and inefficient suppression of proinflammatory cytokines due to the downregulated Sirt‐1‐BDNF‐Nrf2 axis.