ADRB2 and cancer: Catecholamine levels sharply increase during chronic, acute, and sustained stress responses.[41] Acting on ADRB2, the catecholamine hormone activates LDHA to generate lactate, reshaping metabolic pathways in tumor cells to enhance glycolysis, thereby promoting cancer development.[42] Our study found significant increases in NE and E levels after SD, which triggered a cascade response by acting on ADRB2.