CD274 and neoplasm: The expression of CMTM6 (CKLF like MARVEL transmembrane domain containing 6) and SGLT2 (solute carrier family 5 member 2) has been found to stabilize PD‐L1 by inducing internalized PD‐L1 recycle back to the cell membrane.[15, 16] Both CMTM6 depletion and pharmacological inhibition of SGLT2 by canagliflozin exhibited significant anti‐tumor efficiency through triggering PD‐L1 degradation.