The reason might be as following: 1) the highest concentration of zosuquidar we used in our study is 10 × 10−6m, while the serum concentration in clinical is no more than 2 × 10−6m;[37] 2) our study indicates that zosuquidar exerts anti‐cancer effect through PD‐L1 degradation, which means only the patients with PD‐L1 expression could obtain benefits from zosuquidar. Here, CD274 is linked to cancer.