OPA1 and renal fibrosis: Just as shown in Figure 2F–L, Knockdown of circPWWP2A significantly inhibited the up-regulation of mitochondrial division related genes Drp1 and the down-regulation of mitochondrial fusion related genes Opa1 and Mfn1 expression in TGF-β1-induced BUMPT cells, suggesting that circPWWP2A could promote mitochondrial dysfunction in renal fibrosis.